(Silybum marianum / seed)
extracted by tincture in food grade alcohol and purified water

Active Phytochemicals
The tincture of Milk Thistle contains approximately 80% silymarin, the chemical extracted from the seeds. Silymarin is a group of flavonoids: silibinin, silidianin, and silicristin.

Known Uses
Milk Thistle (Silybum marianum) is the most researched plant for the treatment of liver disease.
Medicine Interactions
Antipsychotics - includes butyrophenones (such as haloperidol) and phenothiazines (such as chlorpromazine, fluphenazine, and promethazine)
Phenytoin (Dilantin) - a medication used for seizures
Halothane - a medication used during general anesthesia
Birth control pills or hormone replacement therapy

Medicine Interference
Because Milk Thistle is broken down by the same liver enzymes as the following medicines, it is not recommended that you take the tincture while taking these drugs.
Allergy drugs - such as fexofenadine (Allegra)
Drugs for high cholesterol - including statins such as lovastatin (Mevacor, Altocor)
Anti-anxiety drugs - including alprazolam (Xanax), diazepam (Valium), and lorazepam (Ativan)
Anti-platelet and anti-coagulant drugs (blood thinners) - including clopidogrel (Plavix) and warfarin (Coumadin)
Some cancer drugs
Drugs broken down by the liver

Dosage for Adults: According to "The One Earth Herbal Sourcebook," a tincture regimen of 20 to 40 drops, three times daily, is recommended. Milk Thistle can be taken long term, as long as 4 to 6 years. For specific dosages, depending on the intended use, see Mayo Clinic on-line for more detailed dosage instructions.

Milk thistle is generally regarded as safe. Side effects are usually mild and may involve stomach upset and diarrhea. Some people may get a rash from touching milk thistle plants. Milk thistle should not be used by pregnant or breastfeeding women. People with a history of hormone related cancers, including breast, uterine, and prostate cancer, should not take milk thistle. Do not take milk thistle if you are allergic to ragweed, chrysanthemums, marigolds, chamomile, yarrow, or daisies.

Documentation Sources: University of Maryland Medical Center,, Science Direct, Mayo Clinic

Note: This information is intended to supplement, not substitute for, the expertise and judgement of your physician, pharmacist or other healthcare provider. It should not be construed to indicate that the use of this extract is safe, appropriate, or effective for you. Consult your healthcare provider before taking this tincture.