JAPANESE KNOTWEED
Root
(Fallopia japonica / syn. Polygonum cuspidatum)
extracted by tincture in food grade alcohol

Antiviral / Antimicrobial / Antiviral / Diuretic / Anti-inflammatory / Antitussive / Emmenagogue / Febrifuge


Plant Description/History: Knotweed is native of China, North and South Korea as well as Japan (Seiger, 2005). Outside of its point of origin, Japanese Knotweed was introduced as an ornamental plant. It is widely distributed across the United States and Canada and is found growing wild along rivers.

Constituents-Chemicals & Nutrients: resveratrol*, trans-resveratrol, emodin, emodin monomethyl ether, polydatin (piceid), piceatannol**, physcion, astringin, oxalic acid, alkaloids, phenolics, sterol/terpenes, barium, bromine, calcium, catechin, chrysophanol, citreosein, copper, dimethylhyroxychromone, fallacinol, glucofragulin, glucoside, iodine, iron, isoquercitrin, manganese, methylcourmarin, molybdenum, napthoquinone, nickel, phosphorus, physide, piceid, plastoquinone, polydatoside, polygonin, potassium, protocatechuic acid, quercitrin, questin, questinol, reynoutriin, rheic acid, rubidium, rutin, sulfur, tannin, and zinc.

*Resveratrol has been identified as a potent flavinoid in high concentrations in the root of Japanese Knotweed. The plant contains compounds that are part of a group of organic chemicals called stilbenes, which are polyphenolic compounds attached by an ethylene.[1] The root of Japanse Knotweed is richer in resveratrol than any other known plant and now it is the primary natural source of resveratrol and is considered to have a number of beneficial effects, including anticancer, ant-aethrogenic, anti-oxidative, anti-inflammatory, anti-microbial and estrogenic activity. [2]

**Piceatannol is a metabolite (necessary for metabolism) of resveratrol. It is known to inhibit JAK-1, a key member of the STAT pathway that is crucial in controlling cellular activities in response to extracellular cytokines, and is a COX-2 inductible enzyme involved in inflammation and carcinogenesis. It is known to suppress a wide variety of tumor cells, including leukemia, lymphoma, and cancers of the breats, prostate, colon and mealnoma. [2][3]

Indications:

Cardiovascular - Due to the high content of resveratrol in Japanese Knotweed root, the plant offers benefits for treating cardiovascular disease. Resveratrol decreases the viscosity of the blood and acts as anticoagulant to thin blood, effective in treating cardiovascular disease by reducing thrombosis and embolisms that can block arteries and lead to myocardial and cerebral infarctions.[4] To use Japanese Knotweed Root tincture for cardiovascular disease, you will need to work with a healthcare professional to determine a dosage relevant to your treatment plan.

Cancer - Numerous studies have reported the multiple anti-cancer effects of resveratrol, protecting against both tumor initiation and cancer progression pathways. Japanese Knotweed root has been used as an anti-cancer agent due to its high concentration of resveratrol and corresponding metabolite, piceatannol. To use Japanese Knotweed Root tincture for cancer treatment, you will need to work with a healthcare professional to determine a dosage relevant to your treatment plan.

Weight Loss - To date, resveratrol is the most potent natural polyphenolic compound able to enhance lipid oxidation for fat burning.[5] There are no dosage suggestions available for weight loss planning.

Antioxidant - Daily consumption of 1/2 teaspoon of the tincture, first thing in the morning, provides approx 500 mg of resveratrol which may prevent aging by protecting cellular DNA from free-radical damage.

Lyme Disease - Japanese Knotweed root is known to aid the central nervous system and kill Lyme bacteria. There is much to know about treating Lyme Disease and how this plant root works within the body. Beneficial Botanicals now provides a separate, supplemental page for further information on using Japanese Knotweed Root Tincture to treat Lyme Disease.

The dosages listed here for the Japanese Knotweed Root Tincture are the maximum and minimum dosages outlined by Stephen Harrod Buhner, author of several books on Lyme Disease. Length of dosage varies from 8 to 12 months.

Maximum Dosage:
150 lb adult: 1 teaspoon 3x daily
100 lb adult: 2/3 teaspoon 3x daily
60 lb child: 1/3 teaspoon 3x daily
30 lb child: 1/5 teaspoon 3x daily

Minimum Dosage:
150 lb adult: 1/2 to 3/4 teaspoon 2x daily

Antimicrobial - To inhibit the growth of staph, strep, E. coli, and salmonella the dosage is 1/2 tsp. of the tinctured root first thing in the morning, mid-day and at bedtime.

Antiviral - To inhibit the growth of influenza type A, ECHO virus, and herpes simplex, the dosage is 1/2 tsp. of the tinctured root first thing in the morning, mid-day and at bedtime. Use Japanese Knotweed salve externally.

Cancer - Resveratrol in Japanese Knotweed inhibits cancer cells without harming the liver. Studies indicate the most beneficial use to be in pancreatic, breast, and ovarian cancers.

Neurological - Resveratrol can protect cells from dopaminergic conditions such as Parkinsons Disease. It activates SIRT1 which also treats Alzheimers Disease. Generally, resveratrol may assist in strokes. Polydatin is known to help treat cerebral injuries. Dosage recommendations are not available. Please work with your healthcare provider to determine an appropriate dosage based on your physical condition.

Phytoestrogen Hormone - Trans-resveratrol found in Japanese Knotweed Root is a phytoestrogen which tricks cells into thinking they have estrogen. This attribute is useful when a woman's body is lacking in estrogen to avoid bone loss. Before supplementing, test for hormone levels by saliva testing which will show results of all bio-available estrogen in the body, not just in the blood.

Warnings: Japanese Knotweed Root may interact with several medications, such as blood thinners and drugs metabolized by the P-450 enzyme system in the liver. Consult your healthcare provider before adding to your regiment of drug treatment. When taking capsules of dried powder root, the presence of emodin, a purgative, may irritate the intestine and cause rapid bowel movements. Japanese Knotweed tincture is not suggested for use in pregnant or lactating women, or in people with estrogen-sensitive cancers.

References:
[1] B. Vestano., Y. Chen, N. Zhu, C. Ho, Z. Zhous, & R. Rosen 2000. Isolation and identification of stilbenes in two varieties of Polygonum cupsidatum. J Agric. Food Chem. 48;253-256.
[2] H Piotrowska M. Kucinska, & M. Murias. 2012. Biological activity of piceatannol: leaving the shadow of rexveratrol.
[3] H. Piotowska et al. 2012. Mutation Research vol. 750 (2012) 60-82.
[4] Z. Wang, Y. Huang, J. Zou, K. Cao, Y. Xu, & J.M. Wu 2002. Effects of red wine and wine polyphenol reseveratrol on platelet aggregation in vivo and in vitro. International Journal of Molecular Medicine 9: 77-79.
[5] S. Wang et al. 2015. Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase. International Journal of Obesity 2015; 39: 967-976.




Note: This information is intended to supplement, not substitute for, the expertise and judgement of your physician, pharmacist or other healthcare provider. It should not be construed to indicate that the use of this extract is safe, appropriate, or effective for you. Consult your healthcare provider before taking this tincture.